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    Le misoprostol est un médicament de la famille des prostaglandines PGE1. Anciennement utilisé dans le traitement des ulcères d'estomac et du duodénum et pour prévenir ou traiter les gastrites dues à un traitement anti-inflammatoire non stéroïdien (AINS). Il a aujourd'hui une double AMM autorisation de mise sur le marché pour son utilisation en gynécologie-obstétrique: - Déclenchement du travail sur col défavorable déclenchement du travail lors de l'accouchement. - IVG interruption volontaire de grossesse en combinaison avec de la mifépristone, ainsi que dans les interruption médicale de grossesse des deuxième et troisième trimestres et en cas de mort fœtale Le misoprostol est une prostaglandine de synthèse, analogue aux PGE1 naturelles. Ce médicament est efficace pour la maturation et le déclenchement du travail sur col défavorable. Formule chimique : DIHYDROXY-11-ALPHA, 16 METHYL-16 OXO-9 PROSTENE-13 E OATE-1 DE METHYLE. Le misoprostol a en effet la capacité de provoquer des contractions et la maturation du col de l'utérus. การคะเนปริมาณการเสียเลือดนั้นมักจะต่ำกว่าความเป็นจริง จึงจำเป็นต้องอาศัยทักษะทางคลินิกในการประเมินระดับความรุนแรง โดยทั่วไปอาการและอาการแสดงของการเสียเลือดมักจะยังไม่แสดงออกจนกว่าจะเสียเลือดมากกว่าร้อย 15% ของปริมาณเลือดทั้งหมดในร่างกาย หรือประมาณ 1000 มล.

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