Clonidine and gabapentin

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  1. Clonidine and gabapentin


    Background: Laryngoscopy and endotracheal intubation (L and I) is associated with rise in blood pressure (BP), heart rate (HR), leading to adverse cardiological outcome especially in susceptible individuals. To compare the BP, HR during L and I as well as to evaluate the preoperative sedation status between oral clonidine (Group C) and oral gabapentine (Group G) as premedication for the patients undergoing major surgery under general anesthesia (GA). Materials and Methods: From April 2008 to December 2009; in a prospective, double-blinded, and randomized controlled study; 100 adult patients of either sex, aged 20-45, of American Society of Anesthesiologists status I and II scheduled to undergo major surgery of 1 hour duration, randomly allocated into groups C and G were pre treated with oral clonidine (200 µg) and gabapentin (800 mg) respectively 2 h prior to induction. Preoperative sedation was assessed 2 h after premedication administration. Hemodynamic parameters were noted just before induction, during L and I 1,3,5,7, and10 min after intubation. The results obtained were then analyzed with statistical unpaired “t” test and Chi-square test and compared. Results and Analysis: Preoperative sedation between two groups were similar but group C attenuated HR, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) more significantly before induction, during L and I, 1, 3, and 5 min, following L and I, while comparing with group G. THENS, Ohio — On April 5, Ciera Smith sat in a car parked on the gravel driveway of the Rural Women’s Recovery Program here with a choice to make: go to jail or enter treatment for her addiction. Smith, 22, started abusing drugs when she was 18, enticed by the “good time” she and her friends found in smoking marijuana. She later turned to addictive painkillers, then anti-anxiety medications such as Xanax and eventually Suboxone, a narcotic often used to replace opioids when treating addiction. Before stepping out of the car, she decided she needed one more high before treatment. She reached into her purse and then swallowed a handful of gabapentin pills. advertisement Last December, Ohio’s Board of Pharmacy began reporting sales of gabapentin prescriptions in its regular monitoring of controlled substances. The drug, which is not an opioid nor designated a controlled substance by federal authorities, is used to treat nerve pain.

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    A Moderate Drug Interaction exists between Clonidine ER and gabapentin. View detailed information regarding this drug interaction. Comparative evaluation of oral gabapentin versus clonidine as premedication on preoperative sedation and laryngoscopic stress response. Both oral clonidine and gabapentin are effective in obtunding pressor response to direct laryngoscopy, clonidine being better in terms of controlling HR.

    Nongthombam Ratan Singh Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal - 795 004, Manipur India Source of Support: None, Conflict of Interest: None Background: Laryngoscopy and intubation causes reflex sympatho-adrenal response in the form of tachycardia and hypertension. The present study compared oral gabapentin with oral clonidine for attenuating hemodynamic responses to laryngoscopy and tracheal intubation. Materials and Methods: Ninety patients of American society of Anesthesiologists (ASA) I and II in the age-group of 18-60 years, of either sex, posted for elective surgeries under general anesthesia were randomly divided into three groups (n = 30). On the morning of surgery, the study medications were given orally with sips of water 2 hour pre-operatively as: Group I received 200 μg clonidine, Group II received 900 mg gabapentin, and Group III received placebo. The heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were observed and recorded as 0 minute (baseline) and at 1, 3, 5, and 10 minutes after endotracheal intubation. Results: Oral clonidine (200 mcg) attenuated the increase in systolic blood pressure, diastolic blood pressure, and mean arterial pressure better than oral gabapentin (900mg). The increase in heart rate was significantly attenuated by clonidine as compared to gabapentin and placebo (P How to cite this article: Shreedhara NS, Singh NR, Singh HS, Singh LC, Singh TH. 1 described a rat model of postoperative pain in which incision of the skin, fascia, and muscle of the plantar aspect of the hind paw results in reproducible, quantifiable mechanical allodynia that lasts at least 3 days. 2 The major advantage of this model is that it closely mimics the phenomena of primary and secondary hyperalgesia, 3 which are observed in patients after surgery and may contribute importantly to postoperative pain. 4 The antiepileptic agent gabapentin produces antinociception or reduces hypersensitivity after inflammation or nerve injury in animals and shows effectiveness in the treatment of clinical chronic pain. 5–11 A single subcutaneous dose of gabapentin, 1 h before surgery, dose-dependently (3–30 mg/kg) blocks the development of mechanical allodynia after incision of the hind paw, with a minimum effective dose of 10 mg/kg. 2 Gabapentin is considerably more potent after intrathecal than systemic administration, but has not been evaluated after intrathecal administration in this model. One purpose of the current study was to determine the effectiveness, potency, and duration of action of intrathecally administered gabapentin in this model of postoperative allodynia. The mechanism of action of gabapentin in reducing hypersensitivity in animals or producing analgesia in humans is unknown; however, several hypotheses have been suggested.

    Clonidine and gabapentin

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