Assay of chloroquine by non aqueous titration

Discussion in 'Reliable Pharmacy' started by FOZI, 25-Feb-2020.

  1. ArchE User

    Assay of chloroquine by non aqueous titration


    It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic bases with perchloric acid in anhydrous acetic acid.

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    Acidimetry in Non-Aqueous Titrations In order to perform feasible titrations of weak bases, the solvent system should be selected specifically in such a fashion so as to eliminate as far as possible the competing reaction of water for the proton besides enhancing the strength of the basic species. Nonaqueous Titration Nonaqueous titration is the titration of substances dissolved in nonaqueous the mostcommon titrimetric procedureused in pharmacopoeial assay. The moisture content in nonaqueous titrations should not be more than 0.05%. Advantages of non-aqueous titration 1. Titration of water insoluble drugs. 2. Nonaqueous titration is the titration of substances dissolved in solvents other than water. It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble.

    The Karl Fischer titration for water content is another nonaqueous titration, usually done in methanol or sometimes in ethanol. These assays sometimes take some perfecting in terms of being able to judge the endpoint precisely.

    Assay of chloroquine by non aqueous titration

    Non-aqueous Titrations - Pharmaceutical Analysis Book, Nonaqueous titration of metronidazole tablets

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  6. Aqueous / Non-aqueous Titration. Examples of back titrations Assay for Aspirin Tablets BP • Weigh and powder 20 tablets. To a quantity of the powder containing 0.5 g of Aspirin add 30 ml of 0.5M sodium hydroxide VS, boil gently for 10 minutes and titrate the excess of alkali with 0.5M

    • Titrations - Ministry of Public Health.
    • Nonaqueous titration - Wikipedia.
    • NON-AQUEOUS ACID-BASE TITRATIONS IN PHARMACEUTICAL ANALYSIS.

    Non-Aqueous Titration of Bases with Perchloric Acid. Analysis outlining the method for non-aqueous titration of different bases with perchloric acid in glacial acetic acid using the Schott Instruments TitroLine 7750 Multi-Parameter Titrator, which conveniently combines the features of the potentiometric titrator and the volumetric Karl Fischer titrator. The nonaqueous titrimetric method was applied as parallel validation estimation. This involves volumetric determination of the chloroquine in non- aqueous solvent using 0.1M perchloric acid and crystal violet as indicator. Titrimetric Assay Assay of diclofenac by non-aqueous titration Titre values Table 1 for sample A and the calculation for percent purity are shown below as an example. Samples B to F were similarly treated. The average titre values of 0.1M HClO 4 after titrations for samples A to F, the amount of diclofenac in the sample, percent purity

     
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