Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine weight based dosing 5 mg kg ideal bo Purifying chloroquine phospahte Plaquenil screening form Sometimes when dabrafenib and trametinib are given, the tumor cells activate a stress response called autophagy. Autophagy provides resistance to dabrafenib and trametinib treatment over time making them less effective. Giving hydroxychloroquine with dabrafenib and trametinib may reduce drug resistance and allow more tumor cells to be killed. Hydroxychloroquine is a 4-aminoquinoline in use for more than 30 years for the treatment of malaria, rheumatoid arthritis, and systemic lupus erythematosus. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. Correction The text describing a single-arm skin cancer study evaluating trametinib plus Novartis’s BRAF inhibitor dabrafenib with the addition of hydroxychloroquine for patients. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Trametinib hydroxychloroquine Plaquenil Uses, Dosage & Side Effects -, Phase Ib/II study of hydroxychloroquine in combination. Patients assistance for hydroxychloroquinePlaquenil for autoimmune hepatitis Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma BAMM The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced.. Anticancer autophagy inhibitors attract ‘resurgent’ interest. UPCC 02614 The BAMM Trial BRAF, Autophagy and MEK.. PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL h. ydroxychloroquine sulfate is a. white or practically white, crystalline. powder freely. soluble in water; practically insoluble in alcohol, chloroform, and in ether. The. chemical. name for. This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer.