Drugs administered with chloroquine

Discussion in 'Plaquenil Generic' started by Denchik, 06-Mar-2020.

  1. milawka Guest

    Drugs administered with chloroquine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity 3 but is the only generally available drug with hypnozoitocidal properties, i.e. it kills dormant liver stage parasites and prevents relapse radical cure 1. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Drugs administered with chloroquine

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Could an old malaria drug help fight the new coronavirus?

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  7. An example of an affected drug is praziquantel, among others. Many drugs besides chloroquine may affect the heart rhythm QT prolongation, including amiodarone, dofetilide, mefloquine, pimozide.

    • Chloroquine Oral Uses, Side Effects, Interactions..
    • Chloroquine Uses, Side Effects & Warnings -.
    • Chloroquine Oral Route Proper Use - Mayo Clinic.

    Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women. The drug should be administered with caution to patients having G-6-PD glucose-6 phosphate dehydrogenase deficiency. Auditory Effects. In patients with preexisting auditory damage, chloroquine should be administered with caution. In case of any defects in hearing, chloroquine should be immediately discontinued, and the Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease.

     
  8. Waribriex Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Aralen chloroquine Malaria Drug Side Effects & Dosage Aralen, Chloroquine phosphate chloroquine dosing. Chloroquine Indications, Side Effects, Warnings -
     
  9. fedot New Member

    Description: An exception occurred while processing your request. Rx Side Effects New Plaquenil Guidelines and More. How good is Hydroxychloroquine, and any side effe. Rx Side Effects New Plaquenil Guidelines and More - American.
     
  10. CNSoftware New Member

    Drug Induced Interstitial Lung Disease To minimize the potential morbidity and mortality from drug-induced respiratory diseases, all health care providers should be familiar with the possible adverse effects of the medications they prescribe. The person-to-person variability of a drug response is a major problem in clinical practice and in drug development. The variability in drug.

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  11. Karina Bali XenForo Moderator

    Can you just stop taking plaquenil or do you have to wean off. Aug 27, 2010 Plaquenil is one of those meds you can just stop. My rheumy told me to take a months rest from it once. I asked him about 'tapering' and he said "No - just stop it - and resume after a month."

    The Risk of Retinal Toxicity with Plaquenil