JANUVIA, by itself, is not likely to cause hypoglycemia because it works less when your blood sugar is low. When taken with another medication such as a sulfonylurea or insulin, your dose may need to be lowered. JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. When added to a sulfonylurea (glimepiride) or insulin, patients treated with JANUVIA experienced increased incidence of hypoglycemia. 12.2% for patients treated with JANUVIA glimepiride ± metformin vs 1.8% for placebo glimepiride ± metformin; 15.5% for patients treated with JANUVIA insulin ± metformin vs 7.8% for placebo insulin ± metformin. A lower dose of sulfonylurea or insulin may be required to reduce the risk of hypoglycemia. When added to a sulfonylurea (glimepiride) or insulin, patients treated with JANUVIA experienced a mean increase in body weight. 1.8 lb for patients treated with JANUVIA glimepiride ± metformin vs –0.9 lb for placebo glimepiride ± metformin; 0.2 lb for patients treated with JANUVIA insulin ± metformin vs 0.2 lb for placebo insulin ± metformin. The incidence of selected gastrointestinal adverse reactions in patients treated with JANUVIA and metformin was similar to those of placebo and metformin: nausea (1.3%, 0.8%), vomiting (1.1%, 0.8%), abdominal pain (2.2%, 3.8%) and diarrhea (2.4%, 2.5%). Study evaluating the efficacy and safety of initial combination therapy with sitagliptin and metformin vs metformin or sitagliptin alone: A total of 1,091 patients with type 2 diabetes and inadequate glycemic control on diet and exercise participated in a randomized, double-blind, placebo-controlled factorial study designed to assess the efficacy and safety of sitagliptin metformin compared with respective monotherapies. Sildenafil weight loss Buy viagra over the counter usa Sep 3, 2007. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. JANUMET is a powerful type 2 diabetes medicine that combines 2 prescription medicines, sitagliptin JANUVIA® and metformin, and can lower blood sugar. Warning Rarely, metformin may cause an acid health problem in the blood lactic acidosis. The risk of lactic acidosis is higher in people with kidney problems and in people who take certain other drugs like topiramate. The FDA approved JANUMET® XR (sitagliptin and metformin hydrochloride (HCl) extended-release) tablets, a treatment for type 2 diabetes that combines sitagliptin, which is the active component of JANUVIA® (sitagliptin), with extended-release metformin…. JANUMET XR provides a convenient once-daily treatment option for patients who need help to control their blood sugar. JANUMET XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and extended-release metformin is appropriate. JANUMET XR should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis. JANUMET XR has not been studied in patients with a history of pancreatitis. It is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using JANUMET XR. The FDA approved JANUMET XR based upon a clinical bioequivalence study that demonstrated that administration of JANUMET XR was equivalent to co-administration of corresponding doses of the two individual medications, sitagliptin and metformin HCl extended- release. Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating. Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. metformin and sitagliptin is not for treating type 1 diabetes. Metformin and sitagliptin may also be used for purposes not listed in this medication guide. You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment). Metformin januvia Metformin and sitagliptin - CardioSmart, What is JANUMET® sitagliptin and metformin HCl tablets? Purchase viagra with prescriptionBuy retin a 0.1 online uk Find patient medical information for Januvia Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Januvia Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Sitagliptin and Metformin Tablets Information -. Metformin and sitagliptin Janumet Drug Facts, Side Effects.. Metformin and sitagliptin are often prescribed together for the treatment of high blood sugar levels in patients with type 2 diabetes that can’t be controlled with metformin monotherapy. They work through different mechanism but their effects are synergistic. Januvia sitagliptin is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine. Glucophage metformin is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects. Review the initial combination therapy tolerability profile for JANUVIA® sitagliptin with metformin.