The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). Plaquenil and watery eyes Nivaquine p chloroquine phosphate Plaquenil toxicity guideline The study is based on leflunomide and hydroxychloroquine sulfate the active ingredients of Arava and Plaquenil, respectively, and Arava and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Individualization of Leflunomide Dosing in Rheumatoid Arthritis Patients. with methotrexate and hydroxychloroquine when leflunomide is added to triple therapy. with either leflunomide or. Among those who were on leflunomide, four were on a single drug while one also received methotrexate. Both patients in the other group were on methotrexate and hydroxychloroquine. The onset of neuropathy was on an average 3 months range 45 days to 120 days after the initiation of leflunomide. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine Leflunomide vs Methotrexate Comparison -, Leflunomide Dosing in Rheumatoid Arthritis Patients Hydroxychloroquine sulfate 200 mg tablet Leflunomide Arava® may also raise your risk of getting infections. Let your doctor know if you have signs of an infection, like fever or chills. Hydroxychloroquine Plaquenil® Hydroxychloroquine Plaquenil® is used for rheumatoid arthritis and systemic lupus erythematosus. DMARDs Disease-Modifying Antirheumatic Drugs – CreakyJoints. Peripheral neuropathy in patients on leflunomide.. Leflunomide-hydroxychloroquine combo shows promise in primary Sjögren’s.. The doctor then kept me on my plaquenil and added Leflunomide Arava to replace the methotrexate. My mouth sores went away and I quit having the days of sickness from the methotrexate. There may be something better out there, but for me the Arava has made a big difference. Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Pinho de Oliveira Ribeiro N1, Rafael de Mello Schier A, Ornelas AC, Pinho de Oliveira CM, Nardi AE, Silva AC. The U. S. Food and Drug Administration FDA is adding information on severe liver injury to the Boxed Warning of Arava leflunomide – a drug used to treat rheumatoid arthritis - to.