It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil generic side effects Does plaquenil help with fatigue Chloroquine intercalation Taking plaquenil and drinking alcohol Nov 15, 2016 And then I even used it with Vitamin E suppositories thinking that might help sooth things. No such luck. So I don’t know if the infection is back or I’m just having a reaction to whatever is in the suppositories. I’m curious and will need to find that post about Plaquenil as a disease modifier and not an immunosupressant. Wow, crazy and scary stuff. I don't think I have noticed any serious muscle weakness, but plaquenil was the first medication I was put on over a year ago. I DEFINITELY noticed weight loss/muscle loss, but I also know that is a main symptom of the disease due to muscle inflammation/fibrosis of connective tissues. Plaquenil is not usually considered to be an immunosuppressant even though it may be marked down as that. It is never considered in that way by doctors. It is what we consider a disease "modifier". Precisely why it is so useful in lupus in not exactly known but it has been used for a very long time to treat it. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Disease modifers and how to know when plaquenil is working What next if plaquenil doesn't work? -, Confirmed Plaquenil Muscle Toxicity - Scleroderma - Inspire Signs that plaquenil is eye damagePlaquenil side effects fluid retentionChloroquine casCarbamazepine interaction hydroxychloroquinePlaquenil and log qt It is not clear why Hydroxychloroquine or other antimalarial medications are effective at treating autoimmune diseases, but these medications are usually prescribed when someone is first diagnosed with the disease. It is prescribed as a disease-modifier, in other words, to decrease pain and swelling, and prevent joint damage and disability. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Can plaquenil change blood test results?. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain.