To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Will hydroxychloroquine help osteoarthritis Plaquenil and contraceptive pill Plaquenil Toxicity - Bulls Eye Maculopathy 878 views 70-year-old woman with systemic Lupus erythematosus and clotting problems. She was on the Plaquenil for about eight years and then off the Plaquenil for the last eight years because she developed macular toxicity. Although her vision was hazy, it was stable. In early toxicity there are no visible signs, but field, OCT and mfERG changes can be detected. If abnormalities are present only unilaterally, investigate other causes besides hydroxychloroquine toxicity see “Differential Diagnosis of Bull’s-Eye Maculopathy”. Mechanism of Toxicity Bull's-eye maculopathy due to hydroxychloroquine toxicity. Contributor Jesse Vislisel, MD Photographer Randy Verdick, FOPS September 9, 2013. This patient took hydroxychloroquine for rheumatoid arthritis and her vision dropped to 20/300 as a result of the retinal toxicity. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Typical plaquenil maculopathy oct Expanded spectral domain-OCT findings in the early detection., Hydroxychloroquine-Induced Retinal Toxicity - American. What does hydroxychloroquine doTapering off hydroxychloroquinePlaquenil effectiveness The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules 5’ 7” or higher - up to 400 mg Plaquenil daily Protecting your eyesight when taking Plaquenil Lupus.. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Despite Plaquenil dosing recommendations, retinal toxicity.. Consequently, this clinical finding is often termed bull’s eye maculopathy. Bull’s eye maculopathy will yield the appearance of a ring-shaped scotoma on threshold visual field testing. This explains why patients on Plaquenil therapy should be followed with 10-2 visual fields. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Raymond N. Sjaarda, John T. Thompson, in Retina Fourth Edition, 2006. DIFFERENTIAL DIAGNOSIS. Macular disorders that may be confused with an impending or full-thickness macular hole include cystoid macular edema, solitary drusen, epiretinal membranes, lamellar macular hole, and exudative maculopathy, such as central serous retinopathy or age-related macular degeneration.