Malarial chloroquine resistance

Discussion in 'Hydroxychloroquine' started by combat, 06-Mar-2020.

  1. mag13666 Well-Known Member

    Malarial chloroquine resistance


    Plasmodium species are transmitted by the bite of an infective female mosquito. Occasionally, transmission occurs by blood transfusion, organ transplantation, needle sharing, nosocomially, or from mother to fetus.

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    Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. The WorldWide Antimalarial Resistance Network WWARN is a collaborative platform generating innovative resources and reliable evidence to inform the malaria community on the factors affecting the efficacy of antimalarial medicines. Searches for new drugs against chloroquine-resistant malaria, especially as they relate to analogues of chloroquine and chemosensitizing agents against the different forms of P. falciparum and P. vivax, should benefit greatly from research work in this area

    Travelers going to malaria-endemic countries are at risk for contracting the disease, and almost all of the approximately 1,700 cases per year of malaria in the United States are imported. Malaria is a major international public health problem; 91 countries reported an estimated 216 million infections and 445,000 deaths in 2016, according to the World Health Organization (WHO) World Malaria Report 2017.

    Malarial chloroquine resistance

    Malaria Prophylaxis. The ABCD of Malaria Prophylaxis. Patient, Worldwide Antimalarial Resistance Network - WWARN

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  6. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    • Drug Resistance in the Malaria-Endemic World.
    • Chloroquine-Resistant Malaria The Journal of Infectious..
    • Chloroquine-resistant malaria. edu.

    Malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant. women and nursing mothers. Who should not take chloroquine? People with psoriasis should not take. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a.

     
  7. Snake89 Moderator

    Itching, also known as ‘pruritus,’ can be more than a small annoyance. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine Side Effects Common, Severe, Long Term. Chloroquine Uses, Side Effects & Warnings -
     
  8. Alladdin Well-Known Member

    Plaquenil Uses, Dosage & Side Effects - Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  9. Sanek06 New Member

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length.

    Chloroquine retinopathy - Wikipedia