But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Read more Anxiety over potential eye problems with Hydroxychloroquine is completely unwarranted if the dose is kept below 6mg/kg (2.2lbs) of body weight. Read more See 1 more doctor answer It can cause eye problems so you need to see an ophthalmologist and peridoic screenings. Read more Results are very good, particulary when used alone and better with methotrexate. Hydroxychloroquine sulfate 200 mg tablet Pill pic chloroquine Plaquenil with valcyte Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Namey on plaquenil substitute Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not. Substitutes and alternatives to Plaquenil hydroxychloroquine for uses like Rheumatoid arthritis, Lupus and Malaria Plaquenil hydroxychloroquine Alternatives & Similar Drugs - Skip to full site navigation I was on plaquenil about 5 yrs go and it started messing with me eyes so they took me off. today i went to duke and my dr put me on it agian. she put me on 400mg a day. is that high? i had my eye exam and everthing was fine to take this med again. so im going to try again. i have tryed all the other meds and nothen works. my dr's say im 1 out. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Please provide more detailed information if you want a more specific answer. Read more See 1 more doctor answer Depends on what you are being treated for.... Read more While plaquenyl is a slow acting but effective drug, Prednisone is used in much higher doses in active sle. Arthritis (non-deforming) or arthralgias associated with the disease will have substantial pain relief with a dose this low. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. So other meds like Imuran and Cell Cept (mycophenolate mofetil) also reduce flares, but also increases infection. Read more It depends why you are taking Plaquenil in the first place. Apart from some stomach quiziies, I have never stopped this drug, as long as it demonstrated it is working. Other than that we see a few people who have increased skin pigmentation called "plaquenil ochronosis". The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. Other alternatives to hydroxychloroquine for lupus Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Plaquenil hydroxychloroquine Alternatives & Similar Drugs. Hydroxychloroquine cause weight gainHydroxychloroquine 中文 Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Stomach cramps. Retinal damage. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Alternative" to plaquenil. ProHealth Fibromyalgia, ME.. Potential New Lupus Treatment Outperforms.. It is often an acceptable alternative when Plaquenil causes unacceptable GI problems. Quinacrine can be used together with either Plaquenil or its stronger version Aralen chloroquine for a highly effective combination as the two work together each enhancing the effects of the other. Hydroxychloroquine Plaquenil hydroxychloroquine Arava leflunomide methotrexate methotrexate Sulfasalazine sulfasalazine chloroquine chloroquine I originally took Plaquenil Sanofi but this brand is now discontinued. The generic form of this, on my prescription, gives me serious digestion and stomach upsets to a point I spent months trying to figure out what I thought was irritable bowel syndrome. Has anyone found a good alternative UK brand that doesn't create this side affect.