Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Duloxetine is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old. Duloxetine is also used in adults to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy). Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Report any new or worsening symptoms to your doctor. Duloxetine belongs to the class of medications called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It is used to treat depression and generalized anxiety disorder. It can also be used to treat diabetes-related nerve pain, fibromyalgia, chronic low back pain, and chronic pain from osteoarthritis of the knee. For depression and anxiety, duloxetine works by affecting the balance of chemicals in the brain and other parts of the body. For certain types of pain, duloxetine works by affecting the balance of chemicals in the brain and spinal cord that are involved in the experience of pain. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Order cheap cialis online Sildenafil vs viagra dosage Metoprolol uses and side effects Duloxetine DR Capsules. Dosage Form. Capsule. NDC# 43547-379-06. Strength. 20 mg. Size. 60 Count. Reference Listed Drug. Cymbalta® Product Shelf Life. 24 months Swallow the delayed-release capsule whole with or without food. Do not chew, crush, or break the capsule. per day given as 20 mg two times per day to 60 mg per. Duloxetine DR by Teva Duloxetine belongs to the class of medications called selective serotonin and norepinephrine reuptake inhibitors SSNRIs. It is used to. Endo Pharmaceuticals recently announced the availability of Belbuca, the first buccal formulation of buprenorphine FDA approved for pain. Belbuca is the first and currently the only formulation of buprenorphine that can be delivered by dissolving a film which is placed on the inner lining of the cheek carrying an indication for chronic pain. Buprenorphine didn’t get its start as a treatment for pain. On the surface, this might look like just another one of those pharmaceutical gimmicks that puts a flashy new formulation on the market to rehash an already available medication. Rather, it was initially thought to be helpful for reducing cravings for patients that have an opioid abuse disorder. Buprenorphine is a partial agonist at the mu-opioid receptor (responsible for opioid’s euphoric effects) and as such leads to a less robust euphoric response…voila – less abuse potential! Not long after, researchers discovered buprenorphine has some excellent analgesic qualities as well. The safety profile of buprenorphine presents an additional benefit compared to traditional full agonist opioids, as buprenorphine has a “ceiling effect.” This dramatically reduces the risk of opioid-induced respiratory depression – the common causative factor of opioid overdose-related death due to the partial agonist activity. Opioids block the carbon dioxide feedback loop that is used to stimulate the respiratory center in the brainstem to increase respiratory rate. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine. 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