Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Hydroxychloroquine hydroxyzine interaxtion Chloroquine children Plaquenil back injury Plaquenil and radiotherapy She says I have all signs of Fibro and that may actually be causing me more distress than the antibodies. Anyhow, I was researching to see if Plaquenil interferes with any vitamins or supplements since I take quite a few and read several articles on how Plaquenil depletes Vit D and Calcium. The irony is that Levaquin can cause SEVERE Magnesium Depletion and this magnesium deficiency is one of the main causes of Levaquin Tendonitis. Ironically, giving magnesium inactivates the Levaquin- meaning that you CANNOT take magnesium while you are taking the Levaquin in order to counteract the problem of magnesium deficiency that the Levaquin causes! Normal potassium is between 3.5 and 5.0 millimoles per liter. A level below 3.5 is termed hypokalemia, which is a depletion of potassium that a variety of factors may cause 2. Symptoms of hypokalemia include weakness, fatigue, muscle cramps, constipation and arrhythmias 2. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil depletes magnesium Three Main Causes of Magnesium Deficiency Part 2, Levaquin Drug Interactions are Dangerous and Potentially Disabling Visual field for plaquenil Magnesium supplementation may reduce blood levels of chloroquine, a compound similar to hydroxychloroquine, and decrease its effectiveness. Until more is known, people taking hydroxychloroquine for arthritis who are also using magnesium supplements and are not experiencing relief might try avoiding the supplements or taking them at separate times. Can you take magnesium while taking plaquenil.. What Depletes Potassium? Healthfully. A Practical Guide to Avoiding Drug-Induced Nutrient Depletion. Drugs That Deplete Magnesium by Suzy Cohen 3rd Feb 2015 Suzy Cohen, Suzy Cohen is known as "America's Most Trusted Pharmacist." As a pharmacist for 22 years. Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. Digoxin Moderate Digoxin serum concentrations have been reported to increase when hydroxychloroquine was added. Hydroxychloroquine may inhibit P-glycoprotein P-gp. Digoxin is a substrate for P-gp transport. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes.