Clonidine belongs to a group of medicines known as antihypertensives. Clonidine has been used to treat high blood pressure. Recently it has found new uses (off-label), including: heroin or nicotine withdrawal; severe pain; dysmenorrhea; vasomotor symptoms associated with menopause; ethanol dependence; prophylaxis of migraines; glaucoma; diabetes-associated diarrhea; impulse control disorder, attention-deficit/hyperactivity disorder (ADHD), clozapine-induced sialorrhea. Follow the directions for using this medicine provided by your doctor. Children Hypertension: Children 12 years and older: Initial: 0.2 mg/day in 2 divided doses; increase gradually at 5- to 7-day intervals; maximum: 2.4 mg/day. ADHD (unlabeled use): Initial: 0.05 mg/day; increase every 3-7 days by 0.05 mg/day to 3-5 mcg/kg/day given in divided doses 3-4 times/day (maximum dose: 0.3-0.4 mg/day). 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