Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and diabetes Hydroxychloroquine and back pain Initially, the average adult dose is 400 mg =310 mg base once or twice daily. This may be continued for several weeks or months, depending on the response of the patient. For prolonged maintenance therapy, a smaller dose, from 200 mg to 400 mg =155 mg to 310 mg base daily will frequently suffice. Hydroxychloroquine comes in an oral tablet. Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil 200 mg daily Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine Plaquenil Arava and plaquenil together For treating lupus in adults, the recommended starting Plaquenil dosage is 400 mg once or twice a day. After a while, your healthcare provider may recommend a lower dosage such as 200 mg once daily. The higher the long-term dosage, the more likely that serious Plaquenil side effects especially eye damage may occur. Taking Plaquenil for Various Conditions and Treatment Tips. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily. When SOME patients first start taking Plaquenil and take 2+ tablets from the beginning, sometimes this can affect the eye muscle. When Plaquenil is stopped, the symptoms disappear. This is why many lupus specialists begin with 1 tablet a day 200 mgs and then increase to 2+if necessary. Hydroxychloroquine Tablets - Clinical Pharmacology. Pharmacokinetics. Following a single 200 mg oral dose of hydroxychloroquine sulfate to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days.