Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and candida Plaquenil for uti Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays No. 3, 1990 77 Chloroquine as Intercalator a Hypothesis Revived S. R. Meshnick The mode of action of chloroquine is still controversial. Proposed mechanisms of action include I DNA intercalation, 2 lysosome accumulation and 3 binding to ferriprotoporphyrin IX. Chloroquine diphosphate salt C6628 - Product Information Sheet Author Sigma-Aldrich Corp. Subject This product is a member of the quinoline family with multiple applications. It was originally used as an antimalarial compound. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine diphosphate intercalator Chloroquine Aralen - Side Effects, Dosage, Interactions., Chloroquine as intercalator a hypothesis revived. How to make hydroxychloroquine at homePlaquenil retinopathyChloroquine sulfate The DNA Intercalation Assay This assay is designed to investigate whether a compound intercalates into the DNA double-helix, or binds in the minor groove note 1, leading to unwinding of the DNA. This is a characteristic of a number of inhibitors of DNA-modifying enzymes, such as the topoisomerase inhibitor amsacrine m-AMSA. The DNA Intercalation Assay - Inspiralis. Chloroquine diphosphate salt - Sigma-Aldrich. Chloroquine - FDA prescribing information, side effects and uses. Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV. Chloroquine diphosphate salt DNA intercalator. Also used to increase transfection efficiency. Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinolinebased photoactive drug IAAQ N-4-1-hydroxy-2-dibutylamino ethylquinolin-8-yl-4-azidosalicylamide. C6628-25G C6628-50G Ruη 6-p-cymeneCl 2 2 0.49 mmol was dissolved in water; AgBF 4 1.96 mmol and chloroquine diphosphate 0.98mmol were added under N 2. The mixture was stirred for 20 h at 55 °C and then filtered through celite. The solvent was evaporated and the final product was dried under vacuum.