Mechanism of action of chloroquine in malaria treatment

Discussion in 'Cheap Chloroquine' started by Betty, 25-Feb-2020.

  1. cheker Moderator

    Mechanism of action of chloroquine in malaria treatment


    License: CC BY 2.5Treatment of malaria is aimed at killing the schizonts by one or more mechanisms. Resistance occurs when the parasite develops mechanisms that reduce the effects of the antimalarials or bypasses the mechanisms of the drug.

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    Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Chloroquine is a 4-aminoquinolone compound with a complicated and still unclear mechanism of action. It is believed to reach high concentrations in the vacuoles of the parasite, which, due to its alkaline nature, raises the internal pH. General antimicrobial mechanism of action of chloroquine. Chloroquine accumulates in very high concentrations in the parasite food vacuole Geary et al. 1986. Once in the food vacuole, chloroquine is thought to inhibit the detoxification of heme. Chloroquine becomes protonated to CQ 2+ because the digestive vacuole is acidic pH 4.7

    Monotherapy should be avoided to prevent drug considered a superior antimalarial drug to quinine. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. The American journal of tropical medicine and hygiene, 77(6 Suppl), 29–35. Resistance is a major problem in some parts of the world, e.g., Africa and Southeast Asia; therefore, newer drugs are utilized.

    Mechanism of action of chloroquine in malaria treatment

    WHO Overview of malaria treatment, Antimalarial medication - Wikipedia

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  7. Chloroquine can be prescribed for either prevention or treatment of malaria. This fact sheet provides. information about its use for the prevention of malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of.

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    Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM Mechanism of action As with chloroquine, quinine interferes with heme polymerization. Clinical uses. Multidrug-resistant malaria treatment; Severe malaria, including cerebral malaria intravenous quinine is the drug of choice. However, the fight against malaria becomes more difficult due to mosquitoes resistance to insecticides and Plasmodium falciparum strains which have developed increasing resistance to most of available antimalarial drugs. Chloroquine Nivaquine® was widely used as antimalarial drug and saved many lives for decades.

     
  8. Nick-From Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine - Wikipedia Will you have Infertility with Plaquenil - eHealthMe Mefloquine - FDA prescribing information, side effects and uses
     
  9. Deborah Moderator

    Quinine comes from the bark of a tree native to South America. Chloroquine Resistance in Plasmodium falciparum - microbewiki Chloroquine-Resistant Malaria The Journal of Infectious. Malaria Dissecting chloroquine resistance - ScienceDirect
     
  10. samate Well-Known Member

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