Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Leflunomide methotrexate and hydroxychloroquine Plaquenil withdrawal symptoms Chloroquine and filipina clathrin mediated endocytosis Can i take plaquenil and prednisone together Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. A 57-year-old woman was referred to a retinal specialist with concerns of ocular toxicity from hydroxychloroquine. She complained of blurry vision and flashing lights photopsia. The patient had been taking 400 mg of hydroxychloroquine daily for 10 years for the management of systemic lupus. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Hydroxychloroquine retinal toxicity retina replacement Retinal Toxicity Associated With Hydroxychloroquine and., Hydroxychloroquine-induced retinopathy in a 57-year-old woman Can i take cbd with hydroxychloroquineChloroquine endosomal escape mechanism Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine-Induced Retinal Toxicity - American.. Determine risk for hydroxychloroquine retinal toxicity.. Hydroxychloroquine HCQ is the anchor drug for the treatment of systematic lupus erythematosus SLE and is prescribed for the majority of patients 1. Its primary toxicity is retinal damage, because HCQ binds to and accumulates in the retinal pigment epithelium melanin 2. Combining the results of examinations, HCQ retinal toxicity was deter-mined by 1 ophthalmologist, an expert in retinal diseases. The pattern of retinal toxicity was described as a parafoveal pattern, pericentral pattern, or mixed pattern of retinal toxicity, according to the location of retinal damage. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss.