One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine aps Chloroquine mechanism of action iodine Plaquenil weight gain lupus Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Additionally, knowing the differences among toxicity symptoms in different ethnicities can help validate HCQ toxicity and find signs of it before it causes irreversible damage, Brian Toy, MD, of. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity signs and symptoms What are the symptoms of Plaquenil toxicity?, Protecting your eyesight when taking Plaquenil Lupus. Is plaquenil used to treat msBlack cohosh and plaquenilChloroquine-like drugsPlaquenil hydrochloroquine Signs or symptoms of cardiac compromise have appeared during acute and chronic treatment. Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools eg, ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Plaquenil hydroxychloroquine – New Warnings. Despite Plaquenil dosing recommendations, retinal toxicity.. Early Plaquenil Toxicity Detected without Bull’s Eye.. Sep 15, 2014 Symptoms. In the early stages of HCQ retinal toxicity, most of the patients could be asymptomatic. When the first symptoms start to appear their complaints are the following trouble with reading, diminished color vision, fine visual alteration due to the central or paracentral scotoma. Signs. Biomicroscopy eye exam slip lamp examination. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. The characteristics of patients which may increase of developing toxicity symptoms while taking Plaquenil include an age of more than 60 years old, having renal or hepatic insufficiency or any existing macular degeneration and retinal disease 1.