Hydroxychloroquine surfactant deficiency

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  1. MIXYIL Well-Known Member

    Hydroxychloroquine surfactant deficiency


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    Surfactant Protein B SP-B Deficiency SP-B deficiency is caused by inherited mutations in the surfactant protein-B gene SFTPB on chromosome 2, which leads to a partial or complete absence of surfactant protein B. It is an autosomal recessive condition. We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success. The exact physiopathology of this disease is not known and there is no specific treatment for it. Treatment with exogenous surfactant, systemic steroids, hydroxychloroquine and whole lung lavages had apparent but many times transient effects in individual subjects. Conclusions Overall long-term 5 years survival of subjects with two disease-causing ABCA3 mutations was 20%.

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    Hydroxychloroquine surfactant deficiency

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  3. Ten-year follow up of hydroxychloroquine treatment for ABCA3 deficiency. Williamson M1, Wallis C. Subsequently, surfactant protein gene analysis revealed mutations in the ABCA3 gene. This case of ABCA3 deficient ILD describes a stable clinical course over 10 years and highlights the potential benefit of hydroxychloroquine for this condition.

    • Ten-year follow up of hydroxychloroquine treatment for..
    • Lung disease caused by ABCA3 mutations Thorax.
    • Is treatment with hydroxychloroquine effective in surfactant..

    Surfactant protein C deficiency is characterised by deficiency of the protein and its intracellular accumulation, with subsequent local inflammation and interstitial lung disease. There is no specific treatment, but hydroxychloroquine has been reported to be effective. Surfactant Protein B SP-B Deficiency. SP-B deficiency is caused by inherited mutations in the surfactant protein-B gene SFTPB on chromosome 2, which leads to a partial or complete absence of surfactant protein B. It is an autosomal recessive condition. Amin et al. 2001 reported the benefit of treatment with hydroxychloroquine for surfactant protein C deficiency. Tredano et al. 2004 and Brasch et al. 2004 reported successful treatment with repeated whole-lung lavage, systemic corticosteroids, and azathioprine. A patient reported by Rosen and Waltz 2005 was treated with oral hydroxychloroquine, which had been described as a therapy for.

     
  4. p00w XenForo Moderator

    This is not a list of all drugs or health problems that interact with chloroquine. Covid-19 Before You Stock Up On Chloroquine, Here’s What. Chloroquine diphosphate Supplier CAS 50-63-5 Tocris. Chloroquine Market Growth Opportunities, Driving Factors.
     
  5. mamamoto Well-Known Member

    Chloroquine for research Cell-culture tested InvivoGen Endosomal Acidification Inhibitor. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

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