Chloroquine rheumatoid arthritis mechanism of action

Discussion in 'Canadian Pharmaceuticals Online' started by qazo, 14-Mar-2020.

  1. Sukebe Guest

    Chloroquine rheumatoid arthritis mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

    Psoriatic arthritis response to plaquenil Plaquenil pulmonary Hydroxychloroquine side effects and alcohol What tyoe of arthritis is plaquenil

    It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents.

    For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting.

    Chloroquine rheumatoid arthritis mechanism of action

    What is the mode of action and use of chloroquine in., Chloroquine - Wikipedia

  2. Side effects of plaquenil on pregnancy
  3. The conditions that benefit most from these drugs are those that involve inflammatory processes such as rheumatoid arthritis and lupus. While the exact mechanism of action is not known, many rheumatologists prescribe these medications because of their proven success in relieving symptoms like pain and swelling and preventing the recurrence of.

    • Antimalarials for Rheumatic Conditions - Quinacrine, Chloroquine.
    • Mechanism of action of hydroxychloroquine as an..
    • Mechanisms of action of hydroxychloroquine and chloroquine..

    Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. This open random clinical trial was carried out with a view to assessing the status of chloroquine, the cheapest disease-modifying drug, in the treatment of rheumatoid arthritis. Method A total of. Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in the steady state blood concentrations of chloroquine range 36.6 to 3895 ng.

     
  4. seotut1 User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Sun allergy - Diagnosis and treatment - Mayo Clinic Rheumatoid Arthritis Medication Beware of Sunburn if You. Hydroxychloroquine Uses, Dosage & Side Effects -
     
  5. diamexx Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil - Side Effects, Uses, Dosage, Overdose. Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  6. snegir Well-Known Member

    Healthboards - Immune & Autoimmune - Lupus Plaquenil and. Plaquenil will eventually help your hair loss, but that will be a very slow process over a long period of time since plaquenil builds up in your body pretty slowly. And you should keep your head a scalp protected from the sun as VeeJ said.

    Can I stop my immunosuppressant. - Donovan Hair Clinic
     
  7. marinak XenForo Moderator

    Chloroquine MedlinePlus Drug Information Your doctor may order certain lab tests to check your response to chloroquine phosphate. Your doctor will also test your reflexes to see if you have muscle weakness that may be caused by the drug. If you are taking chloroquine phosphate for a long period of time, your doctor will recommend frequent eye exams.

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