One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine phosphate tablets 500mg Retinal exam for plaquenil Plaquenil 200 mg qd Chloroquine Retinopathy Is Fluorescein Angiography Necessary? ALAN F. CRUESS, MD,* ANDREW P. SCHACHAT, MD,* JAMIE NICHOLL,t JAMES J. AUGSBURGER, MD* Abstract Color fundus photographs and corresponding fluorescein angio grams from 83 patients suspected of having chloroquine retinopathy were reviewed in a retrospective masked study to determine the relative sensitivity of these two photographic. Aug 30, 2011 Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in patients taking a mean daily dose of 329 mg. 23 On the other hand, with strict adherence to a low dose per day, the incidence of retinal abnormalities is. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Chloroquine retinopathy fa Chloroquine Aralen - Side Effects, Dosage, Interactions., Hydroxychloroquine Plaquenil Toxicity and Recommendations. Plaquenil causing psoriasisPlaquenil and cancer risk Hydroxychloroquine or chloroquine ingestion can cause atrophy of the retinal pigment epithelium in the form of a bull’s eye maculopathy in cases of chronic use. Early detection of toxicity prior to the development of the bull’s eye is important, as loss of visual acuity is usually irreversible at that stage. Macular Telangiectasia A cause of bull’s eye maculopathy. Chloroquine Retinopathy - an overview ScienceDirect Topics. Chloroquine - FDA prescribing information, side effects and uses. Jan 21, 2014 Various modalities are used for chloroquine retinopathy detection and classification. Fluorescein angiography FA can reveal the bull's eye pattern of granular hyperfluorescence, but is not useful for the diagnosis of early retinopathy. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Chloroquine retinopathy, also known as bull’s-eye maculopathy, usually occurs in patients undergoing treatment for autoimmune disorders such as rheumatoid arthritis or systemic lupus erythematosus. Premaculopathy is characterized by normal visual acuity but a scotoma to a red target located between 4° and 9° from fixation.