If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Chloroquine phosphate cas Plaquenil and eds WebMD explains the causes, symptoms, and treatment of Sjogren's syndrome, a condition in which your eyes, mouth, and other parts of your body get dried out. Plaquenil or Methotrexate? Support Forums Sjogren's Syndrome. And, Plaquenil takes 2-3 months to build up in your system. So in the event that you are one of the people who is actually able to notice a difference in symptoms, you may not notice them for 2-3 months. Methotrexate and Sjogren syndrome - from FDA reports Summary Sjogren syndrome is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Dizziness. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Pilot Trial in Sjögren’s Shows Potential of Leflunomide., Plaquenil or Methotrexate? - Plaquenil long term Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed. Sjogren's syndrome - Diagnosis and treatment - Mayo Clinic. Will you have Sjogren syndrome with Methotrexate - eHealthMe. Hydroxychloroquine User Reviews for Sjogren's Syndrome at. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. The news has been buzzing about Venus Williams dropping out of the US Open because of Sjogren's syndrome. As the media has discussed, Sjogren's is an autoimmune disease that attacks the tear and salivary glands and generally results in widespread dryness in the body. In addition to dry eyes and.