Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine logp Hydroxychloroquine assistance program Hydroxychloroquine lupus erythematosus Chloroquine lysosomal degradation Background. Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia. It affects millions of people globally. In spite of many antidiabetic drugs that are available, an adequate level of control remains challenging. Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. This study is testing a medication, called hydroxychloroquine HCQ to assess safety and effectiveness to prevent individuals at risk of type 1 diabetes T1D from progressing to type 1 diabetes. HCQ is approved by the U. S. Food and Drug Administration as a treatment for malaria, lupus, and rheumatoid arthritis. The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine HCQ, compared with placebo using frequently sampled intravenous glucose tolerance testing FSIGTT methodology to study changes in insulin secretion and glucose tolerance in subjects at risk for developing Type 2 diabetes. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine diabetes Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs, Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus. Plaquenil and methotrexate for sjogren's syndromeDoes famotidine interfere with plaquenil Some have suggested that hydroxychloroquine may prevent diabetes mellitus. In a retrospective case series, compared with rheumatoid arthritis patients not taking the drug, patients treated with hydroxychloroquine for more than 4 years had a 25% lower risk of developing diabetes mellitus. 20 Hydroxychloroquine An old drug with new relevance Cleveland Clinic.. Reducing Risk of Type 2 Diabetes Hydroxychloroquine Use.. Hydroxychloroquine Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Incidence of diabetes mellitus was identified as a new diagnostic code using a diabetes mellitus-specific medication. Results. Two hundred and twenty-one newly diagnosed diabetes mellitus patients were identified among SLE patients 6795 had taken HCQ and 1833 had never taken HCQ, with an average follow-up period of 5.6 years. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.