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Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; scaly, red skin over a large portion of the body; swollen or tender abdomen; vomiting; yellowing of the skin or eyes. This effect may be worse if you take it with alcohol or certain medicines. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Keep taking it even if you feel better in a few days. Check with your doctor if any of these most common side effects persist or become bothersome: changes in taste; dizziness; headache; nausea; stomach pain. Fluconazole has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes. 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