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    Wellbutrin XL: 150 mg PO q Day; may increase to 300 mg q Day Aplenzin (bupropion hydrobromide): 174 mg PO q Day initially (equivalent to 150 mg bupropion HCl); after 1 week, may increase to usual target dose of 348 mg/day (equivalent to 300 mg bupropion HCL) Zyban: 150 mg PO q Day for 3 days, THEN Increase to 150 mg q12hr; should continue treatment for 7-12 weeks; if patient successfully quits after 7-12 weeks, consider ongoing maintenance therapy based on individual patient risk/benefit Constipation (5-10%) Infection (8-9%) Abdominal pain (2-9%) Anxiety (5-7%) Diarrhea (5-7%) Tinnitus (3-6%) Tremor (3-6%) Nervousness (3-5%) Anorexia (3-5%) Palpitation (2-6%) Myalgia (2-6%) Sweating (2-5%) Rash (1-5%) Sinusitis (1-5%) Weight gain (4%) Chest pain (3-4%) Urinary frequency (2%) Vaginal hemorrhage (2%) Pruritus (2-4%) Vomiting (2-4%) Arthralgia (1-4%) Flushing (1-4%) Migraine (1-4%) Decreased memory ( Nervous system: Abnormal electroencephalogram (EEG), aggression, akinesia, aphasia, completed suicide, delirium, delusions, dysarthria, extrapyramidal syndrome (dyskinesia, dystonia, hypokinesia, parkinsonism), hallucinations, increased libido, manic reaction, neuralgia, neuropathy, paranoid ideation, restlessness, suicide attempt, and unmasking tardive dyskinesia Hypersensitivity to bupropion or other ingredients History of anorexia/bulimia; patients undergoing abrupt discontinuation of ethanol or sedatives including anticonvulsants, barbiturates, or benzodiazepines Coadministration of any other medications that contain bupropion, because seizures are dose dependent Caution in severe hepatic cirrhosis (do not exceed 150 mg every other day), mild-moderate hepatic impairment, head trauma and prior seizure history, CNS tumor, concomitant meds lowering seizure threshold Observe patients for neuropsychiatric symptoms, such as changes in behavior, hostility, agitation, depressed mood, and suicide-related events, including ideation, behavior, and attempted suicide (see Black Box Warnings); therapy may cause delusions, hallucinations, psychosis, paranoia, confusion, and concentration disturbance; symptoms may abate with dose reduction Potential risk of hepatotoxicity Assess blood pressure before initiating treatment with sustained release formulation, and monitor periodically during treatment; risk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activity; use caution in patients with cardiovascular disease May cause weight loss; use caution if weight loss not desirable May cause CNS depression and impair ability to operate heavy machinery Extended-release: Do not administer less than 8 hr apart Seizure risk is dose-related; can minimize risk by limiting daily dose to 522 mg and gradually increasing dose; discontinue permanently in patients who experience seizures May cause sexual dysfunction Screen patients for bipolar disorder and monitor for these symptoms; may precipitate manic, hypomanic or mixed episodes in patients with bipolar disorder Instruct patients to contact a healthcare professional if neuropsychiatric reactions occur Perform thorough cardiovascular assessment to identify risk factors of sudden cardiac death in pediatric ADHD patients Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy; use caution False-positive urine immunoassay screening tests for amphetamines have been reported; confirmatory test (eg, gas chromatography, mass spectrometry) will distinguish bupropion from amphetamines Some patients who stopped smoking reported to have experienced symptoms of nicotine withdrawal, including depressed mood; depression, rarely including suicidal ideation, reported in smokers undergoing a smoking cessation attempt without medication; however, some of these adverse events occurred in patients taking bupropion who continued to smoke Neuropsychiatric adverse events reported in patients without and with pre-existing psychiatric disease; some patients experienced worsening of their psychiatric illnesses; observe patients for occurrence of neuropsychiatric adverse events; patient should stop therapy and contact healthcare provider immediately if agitation, depressed mood, or changes in behavior or thinking that are not typical for patient are observed, or if patient develops suicidal ideation or suicidal behavior; symptoms may persist after discontinuation of therapy; in some cases; monitoring and supportive care should be provided until symptoms resolve Bupropion hydrobromide extended-release tablets are intended for oral use only; inhalation of crushed tablets or injection of dissolved bupropion reported; seizures and/or cases of death reported when administered intranasally or by parenteral injection Not well understood; structurally unrelated to SSRIs, TCAs, MAOIs; does not inhibit the activity of monoamine oxidase or the reuptake of serotonin Norepinephrine dopamine reuptake inhibitor; may act through dopaminergic or noradrenergic pathways The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Wellbutrin Dosage Chart BestPrices2018☀ Wellbutrin SR Bupropion Hydrochloride Sustained-Release Side. The Psychopharmacology of Bupropion An Illustrated Overview.
     
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