I started on it just less than 2 weeks ago, and I'm surrounded by ill people at work and already have a bit of a cold (nothing severe). it is "milder" than a lot of the other dmards in terms of side effects and activity x It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much (eg checking your white blood cell levels), so you shouldn't be completely vulnerable. Even after several years of taking lots of drugs I've not found any difference in the number of colds etc I get, and loads of people on here are teachers etc who get a lot of exposure to colds and coughs without too much problem. Can hydroxychloroquine interfere with the immune system Eye exam before starting the plaquenil Plaquenil and contraceptive pill Purifying chloroquine phospahte Systemic lupus erythematosus SLE is a classic antibody-mediated systemic autoimmune disease characterised by the development of autoantibodies to ubiquitous self-antigens such as antinuclear antibodies and antidouble-stranded DNA antibodies and widespread deposition of immune complexes in affected tissues. Processes at play include immune complex deposition, secretion of collagenases e.g. matrix metalloproteinases by macrophages and neutrophils, cytokine production, complement activation, and formation of autoantibodies. 1. Dry Eye Syndrome. Dry eye syndrome, also known as keratoconjunctivitis sicca, is the most common ocular manifestation of RA. Hi everyone. Just wondered if anyone can tell me whether hydroxy suppresses the immune system. And if so, to what extent. I know it's not as harsh as some of the other drugs but just wondered what people's experiences are. Polly Thank you both, I thought it shouldn't be too bad and that it's pretty mild in comparison to other drugs. Always better to be well informed and I remember the consultant saying its bit a bad time of year to start on it as I've missed all the bugs round Christmas time so thought there may be a slim chance of it being suppressed. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. Plaquenil dissolving immune complexes Elderberry Uses, Side Effects, Interactions, Dosage, and Warning, Ocular Involvement in Rheumatoid Arthritis - American Academy. Side effects of taking hydroxychloroquine Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. The same effects should be expected from both drugs. Do either hydroxychol/Plaquenil put you at risk for.. Hydroxychloroquine and the immune system Hi everyone.. Hydroxychloroquine sulfate and Doxycycline drug interactions.. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine and Hydroxychloroquine. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. PLAQUENIL should be used with caution in patients with hepatic disease or alcoholism, in whom a reduction in dosage may be necessary, or in conjunction with known hepatotoxic drugs. Isolated cases of abnormal liver function tests have been reported; fulminant hepatic failure has also been reported.