Chloroquine interfere nucleic acid biosynthesis

Discussion in 'Canada Drugs' started by shmanci, 08-Mar-2020.

  1. inko XenForo Moderator

    Chloroquine interfere nucleic acid biosynthesis


    Despite drastic containment measures, the spread of this virus is ongoing. SARS-Co V-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans.

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    Feb 17, 2020 The mechanism is that the chloroquine can interfere with the biosynthesis of nucleic acids, thus preventing DNA replication and RNA transcription. Nucleic Acid Synthesis Nucleic acids are synthesized from triphosphate nucleotide precursors by DNA or RNA polymerases using DNA as a monophosphorylated nucleotides are linked together by phosphodiester bonds between the 3′ hydroxyl of ribose or deoxyribose, and the 5′ hydroxyl group of the next sugar in a 5′ to 3′ direction Fig. 14. Chloroquine can inhibit a pre-entry step of the viral cycle by interfering with viral particles binding to their cellular cell surface receptor. Chloroquine was shown to inhibit quinone reductase 2, a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic.

    In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-Co V-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-Co V-1. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease.

    Chloroquine interfere nucleic acid biosynthesis

    Chloroquine Resochin SpringerLink, Nucleic Acid Synthesis - an overview ScienceDirect Topics

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  5. Inhibitors of Nucleic Acid Synthesis. Some antibacterial drugs work by inhibiting nucleic acid synthesis Table 5. For example, metronidazole is a semisynthetic member of the nitroimidazole family that is also an antiprotozoan. It interferes with DNA replication in target cells.

    • Mechanisms of Antibacterial Drugs Microbiology.
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    • ANTIBIOTICS - PROTEIN SYNTHESIS, NUCLEIC ACID SYNTHESIS AND..

    Start studying Chapter 10 Biosynthesis of Nucleic Acids. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Addition of chloroquine to the incubation mixture, at a concentration of 1 or 10 mM, resulted in a significant inhibition of the nucleic acids and protein synthesis. Therefore, this effect on retinal nucleic acid and protein synthesis may be important in the pathogenesis of retinal disease observed during chloroquine therapy. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine’s potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor.

     
  6. buty Guest

    Enlarged or swollen lymph nodes are most commonly found in the neck, including the sides of the neck, front of the neck, and at the back of the neck behind the ears. Are achy/tender lymph nodes a lupus thing? Hydroxychloroquine swollen glands - Doctor answers on. Swollen Lymph Nodes & Glands Causes, Diagnosis, Treatment.
     
  7. neTpo Guest

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine dosage recommendations often ignored. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Chloroquine & Hydroxychloroquine supporting chemo.
     
  8. gvm Well-Known Member

    Hydroxychloroquine Oral Tablet 200Mg Drug Medication Dosage. Hydroxychloroquine Oral tablet 200mg Drug Medication Dosage information. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle.

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