My worst symptoms so far have been raynauds, fatigue, telangiectasias , heart burn, and digital ulcers. I'm fortunate that my lungs have been unaffected up to this point but I'm worried that contracting the virus could cause fibrosis in the lungs and lead to ILD and PAH. Plaquenil screening guidelines ophthalmology How does plaquenil affect the eyes CREST Syndrome and Scleroderma Some people have a type of scleroderma called CREST syndrome or limited scleroderma. Unlike other types, which only affect the arms, legs, and face, this kind can. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies. Hydroxychloroquine Plaquenil Fatigue, joint pain Mild mostly GI symptoms, except for serious eye problems with chronic use at high dosages Antimalarial drug, frequently used to treat lupus and rheumatoid arthritis. Limited research on specific effectiveness in scleroderma. Imatinib mesylate Gleevec Skin fibrosis, pulmonary Moderate Anti-cancer drug. Anybody have any knowledge about this that they can share? I've been trying to do some research but haven't come up with any solid answers. Plaquenil crest syndrome Scleroderma Life Expectancy Johns Hopkins Arthritis Center Ask The., Discontinued Plaquenil.other options? Hydroxychloroquine side effects liver CREST Syndrome is a form of scleroderma that is characterized by least two of the following symptoms calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia. Common symptoms reported by people with CREST syndrome CREST syndrome symptoms, treatments & forums PatientsLikeMe. Scleroderma Treatment General – Standard - Scleroderma.. Hydroxychloroquine Dosage Guide with Precautions -. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. For example, the CREST syndrome Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, Telangeictasias falls into the traditional limited subtype; yet evidence suggests that survival is better in those with the CREST syndrome than an intermediate group of patients in the limited group who have skin changes extending onto the forearms 31. Undifferentiated connective tissue disease UCTD is an autoimmune disease that can affect several systems in the body. Connective tissue disease CTD is classified as undifferentiated CTD when signs and symptoms are consistent with a CTD, but do not fulfill the diagnostic or classification criteria for one of the previously defined CTDs for example, rheumatoid arthritis or lupus.