Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine and chloroquine retinopathy pdf Plaquenil stomach ache Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious Cyanosis with a gray-brown hue that is unresponsive to oxygen occurs when the fraction of hemoglobin existing as methemoglobin exceeds 15%. Most patients are asymptomatic until the methemoglobin fraction is greater than 20% to 30%. Jan 14, 2013 The man ingested two chloroquine tablets 600mg base, and was subsequently found unconscious time to reaction onset not stated and taken to the emergency department. Examination revealed deep peripheral cyanosis, a HR of 96bpm, and a RR of 28 breaths/min. He was only responsive to painful stimuli. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine cyanosis Cyanosis 5-Minute Emergency Consult, Methemoglobinemia causes, symptoms, diagnosis, prognosis. Hydroxychloroquine cause rashPlaquenil safe to takeRetinal changes with the use of hydroxychloroquineWhat tier is plaquenil Methemoglobinemia. Methemoglobinemia MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. Hemoglobin is the protein in red blood cells RBCs that carries and distributes oxygen to the body. Methemoglobin is a form of hemoglobin. With methemoglobinemia, the hemoglobin can carry oxygen. Methemoglobinemia MedlinePlus Medical Encyclopedia. Chloroquine, Reactions Weekly 10.2165/00128415-201214120.. Cyanosis Causes, Symptoms, Types, Treatment Narayana Health. Central Cyanosis This type of cyanosis is usually due to lung or heart diseases and hemoglobin abnormalities, such as sulfhemoglobinemia or methemoglobinemia. A bluish discoloration is often seen on a person's lips and tongue due to central arterial blood desaturation from respiratory and cardiac disorders. Apr 02, 2019 Chloroquine taken in the dose recommended for malaria prophylaxis can reduce the antibody response to primary immunization with intradermal human diploid -cell rabies vaccine. Describe how methemoglobinemia causes cyanosis old question 1 Normal conditions -- RBCs contain hemoglobin with iron in reduced ferrous state Fe2+ 2 Methemoglobin -- iron molecule oxidized to ferric state Fe3+ o Impairs ability of hemoglobin to transport O2 and CO2 to and from tissues.